Two brothers hijack an ambulance after a bank heist goes awry in Ambulance. William James Sharp (Yahya Abdul-Mateen II) is a military veteran, who is desperate for money to pay for cancer surgery for his wife Amy (Moses Ingram). Desperate, Will goes to his adoptive brother Danny (Jake Gyllenhaal) for help and ends up being recruited into taking part in a $32 million bank heist. However, the heist is thwarted with the arrival of the Special Investigation Section of the LAPD and, during the escape, Will shoots police officer Zach (Jackson White) and Danny ends up hijacking the arriving ambulance, along with paramedic Cam Thompson (Eiza González). With Cam tending to Zach in the back, Danny and Will go on a high-speed chase across Los Angeles, with both the LAPD and FBI in tow.
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